笃行致远,磨剑十年——我国阿尔茨海默病早期筛查中的尿液生物标志物研究进展
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国家重点研发计划(2018YFA0108503);首都卫生发展科研专项(首发 2020-2Z-1034)


Study on urine biomarkers in early screening of Alzheimer disease in China
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    摘要:

    随着人口老龄化程度的不断加剧,阿尔茨海默病(AD)的患病人数逐年增加,早筛查、早发 现、早干预已经成为防治 AD 的策略和共识,所以对于无创性外周生物标志物的研究尤为重要。现主要 回顾和总结了近 10 年来国内学者在 AD 尿液生物标志物方面的研究进展,参考文献中的研究结论,绝大 部分来源于对人尿液标本的检测和观察,提示应重视无创性外周生物标志物的探索和应用,为疾病的 早期诊断和早期干预提供新视角和新思路。

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    With the increasing aging of the population, the number of patients with Alzheimer disease (AD) is growing year by year. Early screening, early detection and early intervention have become the strategy and consensus for the prevention and treatment of AD, so the research on noninvasive peripheral biomarkers is particularly important. This article mainly reviews and summarizes the research progress of domestic scholars on urine biomarkers of AD in the past decade. Most of the research findings in the references come from the detection and observation of human urine samples. It suggests that we should pay attention to the exploration and application of noninvasive peripheral biomarkers, which provide a new perspective as well as new ideas for the early diagnosis and early intervention of diseases.

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王蓉,何静.笃行致远,磨剑十年——我国阿尔茨海默病早期筛查中的尿液生物标志物研究进展[J].神经疾病与精神卫生,2022,22(10).
DOI :10.3969/j. issn.1009-6574.2022.10.001.

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  • 在线发布日期: 2022-11-04