Objective To investigate the effect of voice handicap on quality of life in patients with Parkinson disease （PD）. Methods A total of 86 early and middle stage PD patients hospitalized in the Parkinson's Medical Center of Beijing Rehabilitation Hospital affiliated to Capital Medical University from April 2020 to August 2021 were selected as PD group， and 47 healthy controls recruited from society from December 2021 to February 2022 were selected. General data of the subjects were collected. The clinical classification of PD patients was determined by Hoehn & Yahr （H&Y） staging. The motor symptoms of PD patients were evaluated by the International Association of Motion Disorders Unified Parkinson's Disease Rating Scale Part Ⅲ （MDS-UPDRS- Ⅲ）. The quality of life， depression， anxiety， cognitive function， swallowing function and voice status of the subjects were evaluated with 39 items of Parkinson's Disease Questionnaire （PDQ-39）， Geriatric Depression Scale （GDS）， Hamilton Anxiety Scale （HAMA）， Montreal Cognitive Assessment Scale （MoCA）， Swallowing Disorder Questionnaire （SDQ） and Voice Handicap Index （VHI-10）. The scores of VHI-10 and PDQ- 39 in the two groups were compared by covariance analysis. Spearman correlation was used to analyze the related factors of voice handicap and quality of life in early and middle stage PD patients. Results The results of covariance analysis showed that the scores of VHI-10 and PDQ-39 in PD group were higher than those in control group ［8.0（4.0，11.3） vs 0（0，0）； 23.4（15.4，29.0） vs 0（0，3.0）］. The difference was statistically significant （P＜ 0.01）. The PDQ-39 score of male PD patients was lower than that of female patients ［21.2（14.7，26.2） vs 26.3 （18.6，31.4）］， and the difference was statistically significant（Z=-2.41，P＜ 0.05）. Spearman correlation analysis showed that the VHI-10 score of PD patients was positively correlated with age， HAMA score， GDS score and SDQ score （r=0.25，0.31，0.42，0.64；P ＜ 0.05）； PDQ-39 score was positively correlated with H&Y stage， UPDRS-Ⅲ score， GDS score， HAMA score， SDQ score and VHI-10 score （r=0.22，0.24，0.54，0.37，0.33， 0.47； P＜ 0.05）. Multiple linear regression analysis showed that GDS score， VHI-10 score and gender were the influencing factors of quality of life in patients with early and middle stage PD （P＜ 0.01）. Conclusions Early and middle stage PD patients have voice handicap， and voice handicap will reduce their quality of life.