尿沉渣指标对阿尔茨海默病相关神经丝蛋白检测水平的影响
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首都卫生发展科研专项(2020-2Z-1034);国家自然科学基金(82160258)


The effects of urine sediment test indicators on the detection level of Alzheimer-associated neuronal thread protein
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    摘要:

    目的 探讨不同性别人群尿常规指标对阿尔茨海默病相关神经丝蛋白(AD7c-NTP)检测 水平的影响。方法 纳入 2021 年 7— 10 月在桂林医学院附属医院进行健康体检的 314 名受试者,采集 尿液标本进行 AD7c-NTP 酶联免疫吸附剂测定,收集年龄、性别及尿沉渣检测指标数据,分析不同性别 人群的尿沉渣指标对 AD7c-NTP 水平的影响。结果 不同红细胞、白细胞、上皮细胞、小圆上皮细胞、 管型、类酵母菌、结晶水平的男性受试者尿液中的 AD7c-NTP 水平比较,差异无统计学意义(P> 0.05); 男性受试者低电导率、中电导率和高电导率之间的 AD7c-NTP 水平比较[(0.68(0.48,1.40))ng/ml 比 0.50 (0.32,1.06)ng/ml 比 0.34(0.31,0.51)ng/ml],差异有统计学意义(Z=-3.823,P< 0.05)。不同红细胞、白细 胞、上皮细胞、小圆上皮细胞、管型、类酵母菌、电导率水平的女性受试者尿液中的 AD7c-NTP 水平比 较,差异无统计学意义(P> 0.05);高结晶水平的女性受试者尿液中的 AD7c-NTP 水平低于低结晶水平的 女性受试者[0.51(0.33,0.62)ng/ml 比 0.65(0.42,1.18)ng/ml],差异有统计学意义(Z=-2.331,P< 0.05)。 结论 男性尿液电导率和女性尿液结晶可能对 AD7c-NTP 检测水平产生影响。

    Abstract:

    Objective To explore the effects of urine sediment indicators on the detection level of Alzheimer-associated neuronal thread protein (AD7c-NTP). Methods A total of 314 healthy physical examination subjects in Affiliated Hospital of Guilin Medical University from July 2021 to October 2021 were included. Urine samples were collected for AD7c-NTP enzyme linked immunosorbent assay (ELISA) detection. Age, gender, and urine sediment detection indicators were collected and the effects of urinary sediment indexes on AD7c-NTP levels were analyzed. Results The levels of AD7c-NTP in the urine of male subjects with different levels of red blood cells, white blood cells, epithelial cells, small round epithelial cells, casts, yeast like bacteria and crystals showed no statistically significant difference (P > 0.05); In males, the AD7c-NTP levels in low conductivity group [0.68 (0.48,1.40) ng/ml], medium conductivity group [0.50(0.32,1.06) ng/ml] and high conductivity group [0.34(0.31,0.51) ng/ml] showed a significant decreasing trend. The difference is statistically significant (Z=-3.823,P < 0.05). There is no statistically significant difference in AD7c-NTP levels in urine of female subjects with different levels of red blood cells, white blood cells, epithelial cells, small round epithelial cells, tube types, yeast like bacteria and electrical conductivity (P> 0.05); The AD7cNTP levels in urine of female subjects with high crystal level [0.51(0.33,0.62) ng/ml] was lower than that of female subjects with low crystal level [0.65(0.42,1.18) ng/ml]. The difference is statistically significant (Z= -2.331, P< 0.05). Conclusions Among all the urine sediment indicators, the conductivity in male and the crystal in female may affect the detection level of AD7c-NTP.

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金贺,陈国栋,赵丽,王蓉.尿沉渣指标对阿尔茨海默病相关神经丝蛋白检测水平的影响[J].神经疾病与精神卫生,2022,22(11):
DOI :10.3969/j. issn.1009-6574.2022.11.003.

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  • 在线发布日期: 2022-12-22