Objective To analyze the depression， anxiety symptoms and personality traits of patients with psychogenic non-epileptic seizures （PNES）. Methods The general demographic and related clinical data of 22 patients with psychogenic non epileptic seizures （PNES group） and 40 patients with epilepsy （epilepsy group） from the Department of Neurology， Xuanwu Hospital， Capital Medical University from January 2020 to March 2021 were collected. The depression， anxiety and personality traits of the patients were evaluated by Hamilton Depression Scale （HAMD）， Hamilton Anxiety Scale （HAMA） and Minnesota Multiphasic Personality Inventory （MMPI）. The differences between the two groups in general demographic characteristics， clinical data， depression， anxiety and personality traits were compared and analyzed. Results The proportion of seizure with inducing factors and seizure frequency in the PNES group were significantly higher than those in the epilepsy group （P ＜ 0.05）. In the PNES group， the total score of HAMA ［11.80（7.00，15.50） vs 8.50 （5.00，14.00）］， somatic anxiety factor ［5.30（2.00，9.50） vs 3.10（1.00，4.75）］， total score of HAMD ［10.60 （5.50，14.50） vs 7.30（5.00，8.50）］， anxiety somatization factor ［4.00（2.50，5.00） vs 2.80（2.00，4.00）］， sleep disorder factor ［1.80（0，3.00） vs 1.00（0，2.00）］， and the despair factor ［1.10（0，2.00） vs 0.40（0，1.50）］ were significantly higher than those of epilepsy group （Z=2.13，1.98，1.97，2.64，2.15，2.76； P＜ 0.05）. The standard scores of hypochondriasis ［（67.36±2.02） vs （56.79±1.21）］， depression ［（64.09±2.10） vs （52.07±1.97）］， hysteria ［（67.00±1.79） vs （54.62±1.17）］， neurasthenia ［（65.55±2.15） vs （58.40±1.82）］ in MMPI of PNES group were higher than those of epilepsy group； The score of neuroticism ［（71.32±2.05） vs （56.88±1.12）］ and masked factor ［（45.09±2.38） vs （38.57±0.98）］ in PNES group were significantly higher than those in epilepsy group （t=4.77，4.15， 6.00，2.42，6.72，2.53； P＜ 0.05）. The non-social factor in PNES group was lower than that in epilepsy group ［（44.91±2.03） vs （53.24±1.63）］， and the difference was statistically significant （t=-3.10， P＜ 0.01）. Conclusions Patients with PNES have significant depression and anxiety symptoms compared with epileptic patients， and have neurotic and masked personality traits， while epileptic patients have a more obvious tendency of non-socialization.