早期血管内介入栓塞术治疗老年脑动脉瘤的临床疗效观察
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Effects of early intravascular embolization on cerebral aneurysms in elderly patients
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    摘要:

    目的 探讨早期血管内介入栓塞术治疗老年(≥ 60 岁)破裂脑动脉瘤患者的疗效。 方法 选取 2020 年 1 月至 2021 年 12 月贵阳市第二人民医院收治的 82 例老年破裂脑动脉瘤患者为研究 对象,根据行血管内介入栓塞术的时机分为超早期组(发病后 48 h 内,n=25)、早期组(发病后 48~72 h, n=27)和延期组(发病后 72 h 以上,n=30)。比较 3 组患者术后栓塞程度及并发症发生情况。于手术前后 采用美国国立卫生研究院脑卒中量表(NIHSS)评分比较 3 组患者的神经功能,并测定 3 组患者的血管内 皮损伤因子水平。采用格拉斯哥预后评分(GOS)评估预后情况。结果 超早期组完全栓塞率为 88.00% (22/25),高于早期组的 70.37%(19/27)和延期组的 50.00%(15/30),差异有统计学意义(P< 0.05)。延期组 的术后并发症发生率为 33.33%(10/30),高于超早期组的 4.00%(1/25)与早期组的 14.81%(4/27),差异有 统计学意义(P< 0.05)。超早期组与早期组的术后并发症发生率比较,差异无统计学意义(P> 0.05)。 超早期组术后3个月的NIHSS评分为(2.16±0.88)分,低于早期组和延期组的(3.72±0.74)、(6.78±1.05)分, 差异有统计学意义(P< 0.05)。术后 3 个月,超早期组的 vWF、ET-1 水平为(56.39±14.14)ng/ml、(31.76± 10.57)pg/ml,低于延期组的(95.72±20.33)ng/ml、(56.87±11.08)pg/ml,差异有统计学意义(P< 0.05)。超 早期组预后良好率为 92.00%(23/25),与延期组的 60.00%(18/30)和早期组的 77.78%(21/27)比较,差异有 统计学意义(P< 0.05)。结论 老年破裂脑动脉瘤患者行血管内介入栓塞术可取得较好疗效,早期及超 早期实施介入治疗能够加快神经功能恢复,降低并发症发生风险。

    Abstract:

    Objective To investigate the efficacy of early intravascular embolization in the treatment of senile ruptured cerebral aneurysms (≥ 60 years old). Methods A total of 82 senile patients with ruptured cerebral aneurysms, who were admitted to the Second People's Hospital of Guiyang from January 2020 to December 2021, were selected as the study subjects. According to the timing of intravascular embolization, they were divided into three groups: ultra-early group (within 48 h after attack, n=25), early group (within 48 h to 72 h after attack, n=27) and postpone group (more than 72 h after attack, n=30). The embolizasion and complication rate of the three groups were compared. The NIHSS scores of the three groups were compared before and after the operation, and blood samples were collected before and 3 months after the operation to measure the related indexes of vascular endothelial function in the three groups, and the complication rate and prognosis of the three groups were compared. Results The comparison of embolization degree among the three groups showed that the complete embolization rate of ultra-early group was 88.00%(22/25) , which was higher than 70.37% (19/27) in the early group and 50.00% (15/30) in the delayed group (P< 0.05). The incidence of complications in the postpone group was 33.33%(10/30), higher than 4.00% (1/25) in the ultra-early group and 14.81% (4/27) in the early group, with a statistically significant difference (P< 0.05). There was no statistically significant difference in the incidence of complications between the ultra-early group and the early group (P> 0.05). The NIHSS score of ultra-early group was (2.16±0.88) , which was lower than (3.72±0.74) of the early group and (6.78±1.05) of the delayed group, and the difference was statistically significant (P< 0.05). The levels of serum vWF and ET-1 in the three groups were significantly lower than those before operation, and the level of NO was significantly higher than that before operation (P< 0.05). At 3 months after surgery, the vWF and ET-1 levels in the ultraearly group were (56.39±14.14) ng/ml and (31.76±10.57) pg/ml, which were lower than (95.72±20.33) ng/ml and (56.87±11.08) pg/ml in the postponed group, with statistically significant differences (P < 0.05). The good prognosis rate was 92.00% (23/25) in the ultra-early group, which was higher than 60.00% (18/30) and 77.78% (21/27) in the postpone group and early group, with a statistically significant difference (P < 0.05). Conclusions Intravascular embolization can achieve satisfactory results in elderly patients with cerebral aneurysms. Early and ultra-early interventional therapy can accelerate the recovery of nerve function and reduce the risk of complications.

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舒波,出良钊,甘鸿川,周顺军,刘昱甫.早期血管内介入栓塞术治疗老年脑动脉瘤的临床疗效观察[J].神经疾病与精神卫生,2023,23(2).
DOI :10.3969/j. issn.1009-6574.2023.02.004.

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  • 在线发布日期: 2023-04-03