住院精神分裂症患者伴发非酒精性脂肪肝相关因素的性别差异
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上海市精神卫生中心院级课题(2020-YJ15)


Gender differences in factors associated with the development of nonalcoholic fatty liver disease in hospitalized schizophrenic patients
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    摘要:

    目的 探讨住院精神分裂症患者伴非酒精性脂肪肝(NAFLD)的患病率以及影响因 素的性别差异。方法 选取 2020 年 7 月 1 日至 2021 年 6 月 30 日在上海市嘉定区精神卫生中心住院 的 316 例精神分裂症患者为研究对象。采用多因素 Logistic 回归分析住院精神分裂症患者以及不同 性别患者伴 NAFLD 的影响因素。结果 住院精神分裂症患者的 NAFLD 患病率为 41.1%(130/316), 其 中 男 性 患 者 为 42.1%(82/195),女 性 患 者 为 39.7%(48/121)。 多 因 素 Logistic 回 归 分 析 显 示,女 性 (OR=2.345,95%CI=1.159~4.743)、体重指数高(OR=1.445,95%CI=1.296~1.610)、甘油三酯高(OR=2.715, 95%CI=1.709~4.315)、丙 氨 酸 氨 基 转 移 酶(ALT)高(OR=1.019,95%CI=1.002~1.037)、住 院 时 长 长 (OR=1.099,95%CI=1.040~1.162)、合 并 糖 尿 病(OR=2.879,95%CI=1.225~6.768)是 住 院 精 神 分 裂 症 患者伴 NAFLD 的危险因素(P< 0.05)。多因素 Logistic 回归分析显示,男性住院精神分裂症患者体重 指 数 高(OR=1.524,95%CI=1.324~1.753)、甘 油 三 酯 高(OR=2.841,95%CI=1.652~4.887)是 伴 NAFLD 的 危 险 因 素(P< 0.05);女 性 患 者 体 重 指 数 高(OR=1.370,95%CI=1.186~1.582)、血 糖 高(OR=1.982, 95%CI=1.218~3.225)是伴 NAFLD 的危险因素(P< 0.05),发病年龄大(OR=0.939,95%CI=0.889~0.991) 是女性患者伴NAFLD的保护因素(P<0.05)。结论 住院精神分裂症患者的NAFLD患病率较高,与性别、 体重指数、甘油三酯、ALT、住院时长、是否患糖尿病相关,且影响因素存在性别差异,在临床中应重视 防治住院精神分裂症患者发生 NAFLD。

    Abstract:

    Objective To explore the gender differences in the prevalence and influencing factors of nonalcoholic fatty liver disease (NAFLD) in hospitalized schizophrenia patients. Methods A total of 316 schizophrenic inpatients admitted to Shanghai Jiading District Mental Health Center from 1 July 2020 to 30 June 2021 were recruited. Multivariate Logistic regression analysis were applied to analyze schizophrenia inpatients and influencing factors of NAFLD in patients with different genders. Results The prevalence of NAFLD in hospitalized schizophrenics was 41.1% (130/316), with a prevalence of 42.1% (82/195) in male patients and 39.7% (48/121) in female patients. Multivariate Logistic regression analysis showed that the influencing factors of NAFLD in hospitalized schizophrenia patients were female (OR=2.345, 95%CI=1.159-4.743), high body mass index (BMI) (OR=1.445, 95%CI=1.296-1.610), high triglyceride (TG) (OR=2.715, 95%CI=1.709-4.315), high alanine aminotransferase (ALT) (OR=1.019, 95%CI=1.002-1.037), long hospitalized time (OR=1.099, 95%CI=1.040-1.162), diabetes (OR=2.879, 95%CI=1.225-6.768) (P< 0.05). Multivariate Logistic regression analysis showed that high BMI (OR=1.524, 95%CI=1.324-1.753) and high TG (OR=2.841, 95%CI=1.652- 4.887) were the risk factors of NAFLD in male hospitalized schizophrenia patients (P < 0.05); high BMI (OR=1.370, 95%CI=1.186-1.582) and high blood glucose (OR=1.982,95%CI=1.218-3.225) were the risk factors of NAFLD in female hospitalized schizophrenia patients (P < 0.05); elder age of onset (OR=0.939, 95%CI=0.889-0.991) was the protective factor of NAFLD in female hospitalized schizophrenia patients (P < 0.05). Conclusions The prevalence of NAFLD in hospitalized patients with schizophrenia is high, and significantly associated with gender, BMI, TG, ALT, length of hospitalization time and diabetes, and there are gender differences in influencing factors. Therefore, attention should be paid to the prevention and treatment of NAFLD in hospitalized schizophrenia patients in clinical practice.

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孟美玲,韩艳丽,张袁杰,班春霞,陈翔春,于伟霞,王湖,汪崇泽,高存友.住院精神分裂症患者伴发非酒精性脂肪肝相关因素的性别差异[J].神经疾病与精神卫生,2023,23(3).
DOI :10.3969/j. issn.1009-6574.2023.03.004.

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  • 在线发布日期: 2023-05-06