Pyroptosis is a new type of programmed cell death closely related to inflammasomes， mainly mediated by inflammasomes， caspase， and the gasdermins protein family. Research has shown that pyroptosis is associated with neuronal death in ischemic stroke， and some therapeutic drugs can inhibit the process of neuronal cell pyroptosis by inhibiting inflammasomes， thereby reducing nerve injury after ischemic stroke. This paper reviews the process of pyroptosis after ischemic stroke and summarizes anti-pyroptosis related drugs， so as to provide ideas for the prevention and treatment of ischemic stroke.