Objective To investigate the clinical significance of pseudocapsule based extracap-sular resection of pituitary adenomas. Methods Totals of 173 patients who underwent tumor resection fromApril 2015 to July 2016 were selected. All patients were divided into two groups according to pseudocapsulebased extracapsular or intracapsular resection. Total removal rate，biology cure rate and complications were evaluated. Results In the 173 patients，pseudocapsule was found in 90 patients (52.0%) and mostly was found in non-functional and growth hormone secreting pituitary adenoma. No significant differences were found in to-tal removal rate between extracapsular resection group (95.6%) and intracapsular resection group (88.0%). Inpatients with functional pituitary adenoma，biology cure rate of patients in extracapsular resection group wassignificantly higher than those in intracapsular resection group (89.7% vs 71.4%，χ2=4.279，P ＜0.05). Theincidence of cerebrospinal fluid leak during surgery was 47.8% and 41.0% in extracapsular resection group and intracapsular resection group respectively. No cerebrospinal fluid leak was found after surgery. Postoperativepathology confirmed that pseudocapsules had tumor cell infiltration. Conclusions Pseudocapsule based extra-capsular resection is effective and safey for pituitary adenoma. It could increase total removal rate and increase biology cure rate in patients with functional pituitary adenoma without increasing postoperative complications.