Compared with the general population， the risk of cardiovascular death for schizophrenia patients is significantly higher， which is partly related to the use of antipsychotic drugs. Antipsychotic drugs increase the risk of life-threatening pleomorphic ventricular tachyarrhythmia or torsade de pointes （TdP） by prolonging QTc interval. Severe cases may deteriorate into fatal ventricular fibrillation or even sudden cardiac death （SCD）. Gender， age and electrolyte disturbance all have effects on QTc interval prolongation. Different antipsychotic drugs have different effects on QTc interval prolongation. The effects of single antipsychotic therapy and multiple antipsychotic combination therapy on QTc interval were also different. The prolongation of QTc interval caused by antipsychotics is also affected by genetic factors. With the development of pharmacogenetics， many genes related to the prolongation of QTc interval caused by antipsychotics have been identified. This paper reviews the research progress on the influencing factors of QTc interval prolongation caused by antipsychotics， in order to provide reference for clinical diagnosis and treatment.