Objective To explore the correlation between sleep quality and anxiety and depression symptoms in patients with anxiety disorder and depression disorder. Methods From August 2020 to August 2021， a total of 70 inpatients with generalized anxiety disorder， panic disorder and depression in Shenzhou Kangning Hospital were recruited， including 33 cases in depression group and 37 cases in anxiety group. The scores of Hamilton Anxiety Scale （HAMA）， Hamilton Depression Scale （HAMD）， Pittsburgh sleep quality index （PSQI） and Polysomnography data between the two groups were compared and analyzed. Results Among all the enrolled patients in this study， 57.1%（40/70） had PSQI ＞15， and 54.3%（38/70） had sleep efficiency lower than 80%， 48.5%（16/33） had sleep efficiency lower than 80% in the depression group， and 59.5%（22/37） had sleep efficiency lower than 80% in the anxiety group. There were significant differences in HAMD， HAMA， stage N3 sleep and the duration of slow wave sleep （SWS） between depression group and anxiety group （P＜ 0.05）. The HAMD score is positively correlated with PSQI （r=0.416， P＜ 0.05）， and negatively correlated with minimum oxygen saturation （r=-0.416， P＜ 0.05） in depression group. HAMA was positively correlated with PSQI， Stage W and wake time after sleep onset （WASO）（r=0.388-0.476， P ＜ 0.05）， and negatively correlated with rapid eye movement （REM） duration， microarousal index REM and sleep efficiency （r=-0.488- -0.429， P＜ 0.05）. In anxiety group， HAMA was positively correlated with PSQI （r=0.521， P＜0.01）， negatively correlated with sleep period time （SPT） （r=-0.519， P＜ 0.01）. HAMD was positively correlated with PSQI （r=0.424， P＜ 0.01）， and negatively correlated with microarousal index REM and microarousal index non-rapid eye movement （NREM） （r=-0.476- -0.449， P ＜ 0.01）. Conclusions Some patients with depression disorder and anxiety disorder have lower sleep efficiency， and the sleep quality of patients with anxiety disorder and depression disorder is correlated with depression and anxiety symptoms.