As the population aging， the prevalence of dementia remains high. Dementia will deteriorate patients' quality of life， but also bring a heavy burden to the family and society. Therefore， the treatment and prevention of dementia have always been the focus of scientists' attention. In recent years， motoric cognitive risk syndrome （MCR）， as an important research model， can be used to evaluate the decline of individual cognitive ability with reduced walking speed， to understand the pathophysiological mechanism of developing from predementia stage to dementia stage. The purpose of this review was to summary the blood biomarkers and imaging characteristics of MCR， to enhance the understanding of the biological mechanism of MCR.