重复经颅磁刺激治疗帕金森病步态障碍的疗效及生物学机制
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大连市中心医院“登峰计划”项目(2023ZZ020)


Efficacy and biological mechanism of repetitive transcranial magnetic stimulation in the treatment of gait disorder in Parkinson disease
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    摘要:

    帕金森病(PD)是发生在老年期的第二常见的神经系统退行性疾病,包括运动症状与非运 动症状,其中步态障碍严重影响 PD 患者的独立生活质量。目前,左旋多巴药物治疗仍是治疗 PD 运动 症状的首要方法,但对步态障碍的改善较为有限。重复经颅磁刺激(rTMS)是目前非常具有发展前景的 无创神经调节技术,其在改善步态障碍方面具有一定疗效。本文就 rTMS 改善 PD 步态障碍的治疗方案、 治疗靶点、治疗频率、作用机制等方面进行综述,以期对 rTMS 改善 PD 步态障碍提供理论基础及依据。

    Abstract:

    Parkinson disease (PD) is the second most common neurodegenerative disease that occurs in old people,and including motor and non-motor symptoms, in which gait disorder severely affect the quality of life of PD patients in terms of independence. At present, levodopa medication remain the primary method for treating the symptoms of PD,but the improvement of gait disorders still very limited. Repetitive transcranial magnetic stimulation (rTMS) is a very promising non-invasive neuromodulation technology, which has certain efficacy in improving gait disorder. Therefore, this paper reviews the therapeutic plan, therapeutic target, therapeutic frequency, and mechanism of action of rTMS in improving gait disorder of PD. In order to provide theoretical basis and evidence for the use of rTMS in the treatment of PD gait disorder

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牛晓荟,尹文超,王翠.重复经颅磁刺激治疗帕金森病步态障碍的疗效及生物学机制[J].神经疾病与精神卫生,2025,25(5):325-331
DOI :10.3969/j. issn.1009-6574.2025.05.004.

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  • 在线发布日期: 2025-05-22