Multiple sclerosis（ MS） is an immune-mediated inflammatory demyelinating disease of the central nervous system and a leading cause of non-traumatic disability in young adults. Fatigue， characterized by its persistence and complexity， is a common and debilitating symptom among MS patients， significantly impacting rehabilitation outcomes and quality of life. Numerous fatigue assessment tools have been developed internationally for screening and evaluating fatigue in MS. This article reviews and analyzes the characteristics and clinical applications of these tools， aiming to raise awareness among healthcare professionals regarding fatigue management in MS patients and to provide evidence-based references for optimizing fatigue assessment and intervention strategies in clinical practice.