Objective To evaluate the efficacy and safety of olanzapine combined with haloperidol inthe treatment of manic psychosis after traumatic brain injury. Methods Totals of 60 manic patients after trau-matic brain injury treated with olanzapine combined haloperidol were selected from the First People’s Hospital of Xinxiang in June 2015 to December 2016. In the same period，60 patients with mania after brain trauma treat-ed with olanzapine were enrolled as control group. Patients in two groups were treated continuously for 4 weeks. All patients underwent B-R Mania Scale （BRMS）and clinical efficacy total score （CGI-SI）before and after treat-ment for 2 weeks and 4 weeks.The effect of treatment was assessed by the reduction rate of BRMS score and the CCI-SI score after 4 weeks. The adverse reactions in two groups were observed. Results The total effective rate and cure rate of the study group were significantly higher than that of the control group （P＜ 0.05）. There was no significant difference in the BRMS score and CGI-SI score between two groups before treatment （P＞ 0.05）. The BRMS score and CGI-SI score of the study group and control group decreased significantly compared with priortratment（P＜0.05）. After treatment，the BRMS score and CGI-SI score of study group were significantly lower than that of control group （P＜0.05）. There was no significant difference in the incidence of adverse reactions such as dry mouth，tremor，blurred vision，dizziness and headache between two groups （P＞ 0.05）. Conclusions Olanzapinecombined with haloperidol is effective and has quick onset in the treatment of manic psychosis after traumaticbrain injury. It is worthy of popularization and application.