Objective To systematically evaluate antipsychotic-induced motor system adverse reactions in the treatment of psychiatric patients. Methods We searched PubMed， the Cochrane library， CBM， CNKI， VIP and Wan Fang database， collecting randomized controlled trials（ RCT） of various antipsychotic drugs compared with placebo or other psychotropic drugs in comparison to the treatment of psychotic disease. The search period was from the reservoir to November 2017. Evaluating the quality of the study according to Cochrane systematic reviews， Metaanalysis was performed for the results of homogeneous studies by The Cochrane Collaboration's software RevMan 5.3 and the heterogeneous data conducted a descriptive qualitative analysis. Results A total of 81 RCTs involving 21 810 patients were included in the analysis. Considering about the frequency of motor system adverse reactions， on the Parkinson syndrome， risperidone was more than quetiapine； on the extrapyramidal system（ EPS）， olanzapine and haloperidol caused more than aripiprazole， haloperidol caused more than ziprasidone， and ziprasidone caused more than placebo， but the placebo was more than aripiprazole； on the tremor， haloperidol was more than the aripiprazole， risperidone and ziprasidone， risperidone is more than quetiapine and the placebo was more than aripiprazole； haloperidol caused more rigidity than placebo； on the akathisia， haloperidol caused more than aripiprazole， olanzapine and risperidone， olanzapine was more than clozapine， ziprasidone was more than placebo and aripiprazole was lower than placebo. Conclusions The adverse effects of antipsychotics on the motor system are mainly Parkinson， EPS， tremor， rigidity and akathisia. The adverse events of motor system caused by aripiprazole are few， with less statistical significance than placebo. Haloperidol caused more motor-related adverse events， higher than most atypical antipsychotics， which indicates typical antipsychotics are more likely to cause motor side effects than atypical antipsychotics.