Objective To investigate the safety and effectiveness of frameless robot guided stereotactic electroencephalography intracranial electrode implantation surgery for epilepsy patients. Methods From January to July 2018， a total of 26 patients with refractory epilepsy were preoperatively assessed by first stage evaluation， and then the implantation of intracranial electrode was performed by frameless robot guided stereotactic electroencephalography. Long-term intracranial electroencephalography was recorded and epileptogenic zone was localized. Finally resection surgery was performed. Results A total of 205 intracranial electrodes were successfully implanted in all patients. One patient had a small amount of subdural hematoma， and one patient had registration screw loosening. There were no complications such as cerebrospinal fluid leakage， electrode fracture and infection in all patients after the implantation. Conclusions The intracranial electrode implantation under the help of frameless robot guided stereotactic electroencephalography is more minimal invasive and safe.