Objective To evaluate the effectiveness of case management on the schizophrenia patients in community and its health economic effects. Methods From March to June 2015， 50 patients with schizophrenia in Nanlang and Dongsheng town were recruited into case management group. According to the principle of economic and population matching， another 50 patients with schizophrenia in Minzhong town were randomly selected into control group and given basic management services required by the state. The patients of two groups have been followed up for 2 years. All patients were evaluated with the Positive and Negative Symptoms Scale（ PANSS） and a self-designed questionnaire on admission， 1 and 2 years after admission for patients' symptoms and the cost of treatment. The number of inpatients and the time of hospitalization of were compared between the two groups. Results It is shown in the repeated measurement of variance analysis that the intergroup effect， time effect and interaction effect of the two groups were statistically significant in PANSS score， direct cost， indirect cost and total cost（ P＜0.05）. There were statistically difference in each indicators at the time of 1 and 2 years after adimssion（ P ＜ 0.05）. The direct cost， indirect cost and total cost of case management were lower than that of the control group. In the second year， the hospitalization time of the case management group was significantly lower than that of the control group， with statistical significance（ P＜0.05）. There was no difference in hospitalization rate between the two groups. Conclusions Case management can improve the symptoms of schizophrenia patients in community， reduce the length of hospital stay， and reduce the direct and indirect economic cost.