Objective To explore the influence of self-acceptance training on the rehabilitation happiness and self-esteem of schizophrenia patients. Methods From May 2015 to May 2017， a total of 110 cases of schizophrenia patients in the First Affiliated Hospital of Harbin Medical University were selected as the research objects， and were divided by random number table into observation group and control group. The control group（ 55 cases） received conventional nursing service； the observation group（ 55 cases） received the self-acceptance training on the basis of the control group. The Brief Psychiatric Rating Scale（ BPRS） score， Personal and Social Performance Scale（ PSP） score， General Well-Being Schedule（ GWB） score and Self- Esteem Scale（ SES） score before and after 2 months' intervention between the two groups were compared and analyzed. Results The PSP score has a significant increase， while BPRS score decreases in both groups after intervention（ P＜ 0.05）. The PSP score of the observation group is significantly higher than that of the control group， while the BPRS is lower（ P ＜ 0.05）. After intervention， the GWB and SES scores of the observation group are significantly better than those of the control group（ P＜0.01）. Conclusions Self-acceptance training can improve the rehabilitation effect， promote the recovery of social function and improve the self-esteem and rehabilitation happiness of schizophrenic patients.