Objective To analyze the relationship of the serum hs-CRP， uric acid and homocysteine （Hcy） with fatigue degree and cognitive function of patients with Parkinson disease（ PD）. Methods A total of 120 patients with PD who had been diagnosed in Handan Central Hospital from January 2016 to October 2017 were selected as the study group. Another 50 cases with healthy people participated in physical examination were recruited as the control group at the same time. The serum hs-CRP， uric acid and Hcy were compared between the two groups. The study group can be divided into subgroup A with the score of MMSE equal or less than 20， and subgroup B with the score of MMSE over 20. According the Fatigue Scale-14（ FS-14）， the study group were divided into subgroup C with the score over 8， and subgroup D with the score equal or less than 8. The correlation of serum hs-CRP， uric acid and Hcy with FS-14 score and MMSE scores of patients were analyzed in the study group. Results The serum hs-CRP， Hcy and FS-14 score of the study group were significantly higher than those of the control group. However， the value of uric acid and the score of MMSE of the study group were lower. All the differences were statistically significant（ P＜0.05）. The patients in the subgroup A had a higher serum hs-CRP and Hcy， and a lower serum uric acid， MMSE score and FS-14 score than the patients in the subgroup B， and the differences were statistically significant（ P＜0.05）. The serum uric acid value and the score of FS-14 of the subgroup C were both lower than those of the subgroup D， and the differences were statistically significant（ P＜0.05）. The level of serum hs-CRP and Hcy were negatively correlated with the score of MMSE （r=-0.303， -0.327； P＜0.05）. The blood uric acid was positively correlated with the score of MMSE（ r=0.294， P＜0.05）. There was no correlation between serum hs-CRP， uric acid， Hcy and the score of FS-14（ P＞ 0.05）. Conclusions Serum hs-CRP， uric acid and homocysteine levels were related to cognitive function of PD， but there was no significant correlation with fatigue.