Objective To explore the effects of closed training on coping style and quality of life in patients with schizophrenia during rehabilitation. Methods A total of 100 patients with schizophrenia who were treated in Wuhan Mental Health Center from July 2014 to July 2017 were selected and randomly divided into two groups according to the digital randon table method， with 50 cases in each. The patients in the control group were given routine nursing care. Closed training was carried out in the observation group on the basis of the control group. The scores of Morningside Rehabilitation Status Scale（ MRSS）， Coping Style Questionnaire （CSQ）， APGAR and Generic Quality of Life Inventory-74（ GQOLI-74） were compared between the two groups. Results The dependence， inactivity， symptomatic behavior abnormalities and social score of MRSS in the observation group were significantly lower than those in the control group（ P＜0.05）. There was no significant difference in the scores of CSQ， APGAR， GQOLI-74 between the two groups before training（ P＞0.05）. After the training， both groups improved significantly， and the scores of the observation group were significantly higher than those in the control group（ P ＜ 0.05）. Conclusions Closed training can effectively improve the coping style and quality of life in convalescent patients with schizophrenia.