Natto is a traditional Japanese food. Nattokinase is an alkaline serine protease secreted by Bacillus natto， which has fibrinolytic activity. Based on comprehensive analysis of basic and clinical research， it shows that nattokinase has a certain effect on anti-platelet， anticoagulant， thrombolytic， lowering blood pressure and lowering blood lipids. Based on the results of relevant literatures and expert discussions， we propose recommendations about using nattokinase in cardiovascular risk population， in order to provide auxiliary advice when doctor guide public to use nattokinase.