Stroke is dominated by ischemic stroke， which has a high incidence and recurrence rate. It is a non-communicable disease with increasing mortality and disability rate. Studies have shown that microRNA-125（ miR-125） can participate in various pathophysiological processes of ischemic stroke， and the expression of miR-125 is significantly correlated with the prognosis of intravenous and intravascular thrombolysis. This article summarizes the research progress of the correlation between miR-125 and ischemic stroke.