Dopamine supersensitivity psychosis （DSP） refers to the development of rebound psychosis， increased drug tolerance， and tardive dyskinesia （TD） after chronic and high dose of antipsychotic drugs in patients with schizophrenia. The mechanism of DSP is currently unclear， and there is a lack of effective treatment. However， the prevalence of DSP remains high in patients with schizophrenia， especially in treatmentresistant schizophrenic patients. Many clinical studies have focused on DSP in recent years. Mastering its mechanisms of occurrence and effective treatment can shorten the disease course and improve the overall prognosis of patients. Therefore， this paper presents a review of the pharmacological mechanisms and treatment of DSP.