Objective To explore the clinical characteristics of untreated schizophrenic patients with violence， and analyze the correlation between violence and the levels of thyroid hormone and C-reactive protein （CRP）. Methods A total of 130 antipsychotic-naive patients with schizophrenia， who were hospitalized in Tianjin Anding Hospital from November 2017 to December 2019 were recruited. According to the history of violent attack before admission， they were divided into violence group （n=72） and non violence group （n=58）. The positive and negative symptom scale （PANSS） was used to assess the clinical symptoms of the patients. The levels of total triiodothyronine （TT3 ）， total thyroxine （TT4 ）， thyrotropin （TSH） and CRP were measured by peripheral blood. The data were analyzed by SPSS 23.0 professional statistical software. Results No significant differences were found in gender， age， education level， marriage， disease course and family history between the two groups （P ＞ 0.05）. There were no statistical differences in TT4 ［（99.35±25.37） nmol/L vs （93.87±22.38） nmol/L］ and TSH ［1.89 （1.23，2.47） μIU/mL vs 1.75 （1.07，2.62） μIU/ml］ （P＞0.05）. The level of TT3 ［（1.74±0.34） nmol/L vs （1.63±0.24） nmol/L］ and CRP ［1.35 （0.47， 4.49） mg/L vs 0.61 （0.35， 1.33） mg/L］ of the violence group were higher than those of the non violence group， and the differences were statistically significant （P ＜ 0.05）. The differences in excitability/hostility factor ［（16.89±3.59） vs （15. 43±3.34）］ and positive factor ［（17.28±3.91） vs （15.43±3.34）］ of the five dimensions of PANSS were statistically significant （P＜ 0.05）. Spearman correlation analysis showed no significant correlation between TT3 and CRP levels and PANSS five-dimension symptoms in the violence group. After further gender grouping， it was found that only female TT3 levels were positively correlated with excitability/hostility factors （r=0.378， P ＜ 0.05）. Conclusions Violence may be associated with TT3 and CRP in antipsychotic-naive patients with schizophrenia. Female schizophrenics with higher TT3 levels have higher scores of excitability/hostility factor， and are at greater risk of violence.