Coenzyme Q10 （CoQ10） is a fat-soluble antioxidant in the human body， which participates in the transmission process of the mitochondrial respiratory chain. At present， a large number of studies have found that CoQ10 has certain treatments in a variety of diseases （such as heart disease and chronic kidney disease， etc.）. In some studies exploring the pathogenesis of neurodegenerative diseases， it has been found that this type of disease is partly related to oxidative damage caused by mitochondrial dysfunction. Therefore， in recent years， the therapeutic effect of CoQ10 in neurodegenerative diseases has also received attention， and related cell animal experiments and clinical trials have been reported. This review focuses on the progress of CoQ10 in this field， mainly focusing on Alzheimer disease， Parkinson disease and Huntington disease.