High disability rate and high mortality is one of the main characteristics of acute stroke. Very early activities and rehabilitation after stroke have been considered as an important part of the treatment and nursing of advanced stroke centers. We reviewed the recommendations in guidelines for very early post-stroke activity， the safety and efficacy of relevant intervention studies， the status of implementation， and the status of very early post-stroke activity in patients treated with intravenous thrombolysis. This review is intended to provide evidence for very early post-stroke activity in patients with acute ischemic stroke.