Objective To analyze the influencing and predictive factors of cognitive behavioral therapy （CBT） on the treatment effect of social anxiety disorder （SAD）， and explore the significance of predictive factors to improve the treatment effect. Methods Based on the scoping review method， researches related to predictors of the effect of CBT in the treatment of SAD were searched in Chinese databases （CNKI， Wanfang， VIP， CBM） and foreign databases （PubMed， Embase， Cochrane Library） from the establishment of the database until October 2021. Two researchers independently extracted and analyzed the data of the included literature. Results A total of 22 articles were included. The results showed that the cognitive and functional status of the brain， the heart rate variability before treatment， the treatment experience of patients， the competence of therapists， and the score of SAD related symptom scale could all affect and predict the therapeutic effect of CBT. Conclusions Therapists' evaluation of predictors of the effect of CBT on SAD is conducive to timely adjustment of treatment plan and selection of the best treatment for patients， which is of great significance for the development of precision medicine.