Research progress on neural mechanism of executive dysfunction in obsessive-compulsive disorder
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    Abstract:

    Executive dysfunction is an important feature of obsessive-compulsive disorder (OCD). Neuroimaging and genetic studies have shown that the functional abnormalities in cortico-striatal-thalamocortical circuits, parietal lobes, cerebellum and other brain regions, as well as genetic variants in serotonin and glutamate systemsin patients with OCD, may lead to their executive dysfunction. However, due to the heterogeneity of OCD and the complexity of executive function, no consistent conclusions have been drawn about the neural mechanism of executive dysfunction in OCD. Integrating the neural mechanisms and genetic patterns of executive dysfunction in OCD will help deepen the understanding of the pathogenesis of OCD; combining neuroimaging and genetic findings to identify markers will help provide new directions in the identification and intervention of executive dysfunction in OCD. This article reviews the brain structure, neural mechanism of brain function and genetic research of executive dysfunction in OCD.

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Li QX,Zhang ZM. Research progress on neural mechanism of executive dysfunction in obsessive-compulsive disorder[J].Journal of Neuroscience and Mental Health,2022,22(11):827-832.DOI:10.3969/j. issn.1009-6574.2022.11.012.

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  • Online: December 22,2022
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