Alzheimer disease（ AD） is a serious threat to healthy aging. The difficulty lies in its complicated pathogenesis， unknown etiology and lack of effective intervention means. The use of multi-omics technology to explore the spatio-temporal variation rules in the occurrence and development of AD from the gene level to the metabolic level may provide evidence for identifying risk factors， discovering early biomarkers， targeting early intervention time windows， and formulating effective intervention targets. In this paper， we summarize the research progresses of multi-omics technology in AD， aiming to provide references for the related research.