Recent studies have shown abnormalities in neurometabolism in brain regions such as prefrontal cortex， anterior cingulate gyrus， and striatum in a variety of mental disorders. Currently， magnetic resonance spectroscopy is an important tool for studying cerebral neurometabolism. This paper reviews the latest progress in the neurometabolism of three functional brain regions， prefrontal cortex， anterior cingulate gyrus， and striatum， in bipolar disorder and obsessive-compulsive disorder， with the aim of providing references for further exploring the possible neurobiological mechanisms of the two disorders and the possible neural pathways of their comorbidities.